Diagnóstico y Relación con Enfermedades Sistémicas

Manuscripts (WOS-Science Citation Indexed (SCI) Journals)

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study. Oral Diseases.

Autores: Gilligan, G., Panico, R., Lazos, J., Morelatto, R., Belardinelli, P., Criscuolo, I., … González-Arriagada, W. A.

CR5/CCL5 axis is linked to a poor outcome, and inhibition reduces metastasis in oral squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 1-12.

Autores: González-Arriagada, W. A., Coletta, R. D., Lozano-Burgos, C., García, C., Maripillán, J., Alcayaga-Miranda, F., … & García, I. E.

Histopathological parameters reported in microinvasive oral squamous cell carcinoma: a systematic review. Medicina oral, patologia oral y cirugia bucal, 25675.

Autores: Saldivia-Siracusa, C., Araújo, A. L., González-Arriagada, W. A., Nava, F. J., Hunter, K. D., Lopes, M. A., … & Santos-Silva, A. R.

Perineural invasion predicts poor survival and cervical lymph node metastasis in oral squamous cell carcinoma. Medicina Oral, Patologia Oral y Cirugia Bucal, 25916-25916. 

Autores: Martínez-Flores, R., Gómez-Soto, B., Lozano-Burgos, C., Niklander, S. E., Lopes, M. A., & González-Arriagada, W. A.

Overexpression of heat‐shock protein 47 impacts survival of patients with oral squamous cell carcinoma. Journal of Oral Pathology & Medicine. 

Autores: da Costa, B. C., Dourado, M. R., de Moraes, E. F., Panini, L. M., Elseragy, A., Téo, F. H., … González-Arriagada, W. A. & Coletta, R. D.

A novel porous hydrogel based on hybrid gelation for injectable and tough scaffold implantation and tissue engineering applications. Biomedical Materials, 18(4), 045014.

Autores: Hidalgo, C., Méndez-Ruette, M., Zavala, G., Viafara-García, S., Novoa, J., Díaz-Calderón, P., … González-Arriagada, W. A. & Acevedo, J. P.

Whole-exome sequencing of oral epithelial dysplasia samples reveals an association with new genes. Brazilian Oral Research, 37.

Autores: Adorno-Farias, D., Santos, J. N. D., Gonzalez-Arriagada, W., Tarquinio, S., Santibanez Palominos, R. A., Martin Martin, A. J., & Fernandez-Ramires, R.

HER2 classification in breast cancer cells: A new explainable machine learning application for immunohistochemistry. Oncology Letters, 25(2), 1-9. 

Autores: Cordova, C., Muñoz, R., Olivares, R., Minonzio, J. G., Lozano, C., Gonzalez, P., … González-Arriagada, W. A. & Olivero, P.

Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma. Frontiers in oncology. 

Autores: Wahbi, W., Dourado, M. R., Elseragy, A., da Costa, B. C., Teo, F. H., Guimaraes, G. N., … González-Arriagada, W. A. & Coletta, R. D.

Therapeutic Perspectives of HIV-Associated Chemokine Receptor (CCR5 and CXCR4) Antagonists in Carcinomas. International Journal of Molecular Sciences, 24(1), 478. 

Autores: González-Arriagada, W. A., García, I. E., Martínez-Flores, R., Morales-Pison, S., & Coletta, R. D.

Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer. Nature Communications, 13(1), 6725.

Autores: Busso-Lopes, A. F., Neves, L. X., Câmara, G. A., Granato, D. C., Pretti, M. A. M., Heberle, H., … & González‐Arriagada, W. A., Paes Leme, A. F.

Acquired oral syphilis: A multicenter study of 339 patients from South America. Oral Diseases, 28(6), 1561-1572.

Autores: de Andrade, B. A. B., de Arruda, J. A. A., Gilligan, G., Piemonte, E., Panico, R., Molina Avila, I., … & González‐Arriagada, W. A., Romañach, M. J.

Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas. Oral Diseases, 28(4), 1085-1093.

Autores: Dourado, M. R., Machado, R. A., Paranaíba, L. M. R., González‐Arriagada, W. A., da Silva, S. D., Sawazaki‐Calone, Í., … & Coletta, R. D.

CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity. Front. Oncol. 12:928498.

Autores: Contreras-Kallens P, Gálvez-Jirón F, De Solminihac J, Elhusseiny A, González-Arriagada WA, Alcayaga-Miranda F, Noelle RJ and Pino-Lagos K

MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review. Medicina Oral, Patología Oral y Cirugía Bucal. 2022;27(1):e77.

Autores: Niklander S, Guerra D, Contreras F, González-Arriagada W, Marín C.

SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level. Scientific reports. 2021;11(1):1-11.

Autores: Pennacchiotti G, Valdés-Gutiérrez F, González-Arriagada WA, Montes HF, Parra JMR, Guida VA, et al.

Impact of head and neck radiotherapy on the longevity of dental adhesive restorations: A systematic review and meta-analysis. The Journal of Prosthetic Dentistry. 2021.

Autores: Palmier NR, Troconis CCM, Normando AGC, Guerra ENS, Araújo ALD, Arboleda LPA, González-Arriagada WA et al.

Assessment of mandibular kinematics values and its relevance for the diagnosis of temporomandibular joint disorders. Journal of Dental Sciences. 2021;16(1):241-8.

Autores: Leissner O, Maulén-Yáñez M, Meeder-Bella W, León-Morales C, Vergara-Bruna E, González-Arriagada WA.

Lappalainen R. Feasibility of Near-Infrared Spectroscopy for Identification of L-Fucose and L-Proline—Towards Detecting Cancer Biomarkers from Saliva. Applied Sciences. 2021;11(20):9662.

Autores: Hurskainen MO, Sarin JK, Myllymaa S, González-Arriagada WA, Kullaa A.

Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas. Oral Diseases. 2021.

Autores: Dourado MR, Machado RA, Paranaíba LMR, González‐Arriagada WA, da Silva SD, Sawazaki‐Calone Í, et al.

Plasmacytoma and plasma cell myeloma affecting the jaws: a multi‐institutional collaborative study. Journal of Oral Pathology & Medicine. 2021.

Autores: de Souza LL, de Cáceres CVBL, Vargas PA, Lopes MA, Santos‐Silva AR, Gomes da Silva W, González-Arriagada WA et al.

Acquired oral syphilis: A multicenter study of 339 patients from South America. Oral Diseases. 2021

Autores: de Andrade BAB, de Arruda JAA, Gilligan G, Piemonte E, Panico R, Molina Avila I, González-Arriagada WA et al.

Optogenetic control of cancer cell survival in ChR2‐transfected HeLa cells. International Journal of Experimental Pathology. 2021;102(6):242-8.

Autores: Córdova C, Lozano C, Rodríguez B, Marchant I, Zúñiga R, Ochova P, González-Arriagada WA.

Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets. Scientific reports. 2020;10(1):1-8.

Autores: Rivera C, Crisóstomo MF, Peña C, González-Díaz P, González-Arriagada WA.

The adverse effects of radiotherapy on the structure of dental hard tissues and longevity of dental restoration. International journal of radiation biology. 2020;96(7):910-8.

Autores: Muñoz MA, Garín-Correa C, González-Arriagada W, Quintela Davila X, Häberle P, Bedran-Russo A, et al.

The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review. Medicina oral, patologia oral y cirugia bucal. 2020;25(1):e96.

Autores: Fonseca JM, Troconis CCM, Palmier NR, Gomes-Silva W, de Pauli Paglioni M, Araújo ALD, González-Arriagada WA et al.

Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients. Oral surgery, oral medicine, oral pathology and oral radiology. 2020;130(6):700-7. E2.

Autores: Domingueti CB, Castilho DAQ, de Oliveira CE, Janini JBM, González-Arriagada WA, Salo T, et al.

Exophytic swelling of the buccal mucosa in a young female patient. Oral surgery, oral medicine, oral pathology and oral radiology. 2019;127(4):267-71. 

Autores: Martínez R, Marín C, Niklander S, Marshall M, González-Arriagada WA.

Clinicopathological significance of expression of mir-26a, mir-107, mir-125b and mir-203 in head and neck squamous cell carcinomas. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2019;128(1):e27.

Autores: González-Arriagada WA, Olivero P, RodrÍguez MB, Lozano-burgos C, De Oliveira CE, Della Coletta R.

Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth. Medicina oral, patologia oral y cirugia bucal. 2019;24(3):e354.

Autores: Domingueti C-B, João-Baptista-Macuco Janini L-M, Paranaíba R, Lozano-Burgos C, Olivero P, González-Arriagada W-A.

Agrin has a pathological role in the progression of oral cancer. British journal of cancer. 2018;118(12):1628-38.

Autores: Rivera C, Zandonadi FS, Sánchez-Romero C, Soares CD, Granato DC, González-Arriagada WA, et al.

Proteostasis and mitochondrial role on psychiatric and neurodegenerative disorders: current perspectives. Neural plasticity. 2018;2018.

Autores: Olivero P, Lozano C, Sotomayor-Zárate R, Meza-Concha N, Arancibia M, Córdova C, González-Arriagada WA et al.

Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer. Oncology letters. 2018;16(5):6795-800.

Autores: Mikkonen JJ, Singh SP, Akhi R, Salo T, Lappalainen R, González‑Arriagada WA, et al.

Assessment of association between muscular diagnosis in temporomandibular disorders with mandibular kinematics. CRANIO®. 2018.

Autores: Maulén-Yáñez M, Meeder-Bella W, Videla-Jiménez PJ, González-Arriagada WA.

Intracellular aggregated TRPV1 is associated with lower survival in breast cancer patients. Breast Cancer: Targets and Therapy. 2018;10:161.

Autores: Lozano C, Córdova C, Marchant I, Zúñiga R, Ochova P, Ramírez-Barrantes R, González-Arriagada WA et al.

Clinicopathological significance of chemokine receptor (CCR 1, CCR 3, CCR 4, CCR 5, CCR 7 and CXCR 4) expression in head and neck squamous cell carcinomas. Journal of Oral Pathology & Medicine. 2018;47(8):755-63.

Autores: González‐Arriagada WA, Lozano‐Burgos C, Zúñiga‐Moreta R, González‐Díaz P, Coletta RD.

Clinicopathological significance of miR‐26, miR‐107, miR‐125b, and miR‐203 in head and neco carcinomas. Oral diseases. 2018;24(6):930-9.

Autores: González‐Arriagada W, Olivero P, Rodríguez B, Lozano‐Burgos C, De Oliveira C, Coletta R.

Efficacy of low-level laser therapy as an auxiliary tool for management of acute side effects of head and neck radiotherapy. Journal of Cosmetic and Laser Therapy. 2018;20(2):117-22.

Autores: González-Arriagada WA, Ramos LMA, Andrade MAC, Lopes MA.

Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer. Nature communications. 2018;9(1):1-17.

Autores: Carnielli CM, Macedo CCS, De Rossi T, Granato DC, Rivera C, Domingues RR, González-Arriagada WA et al.

SciELO (Scientific electronic library online) and Scopus indexed journals

Oral complications in cancer patients. Frontiers in Oral Health, 3, 1116885.

Autores: González-Arriagada, W. A., Ottaviani, G., Dean, D., Santos-Silva, A. R., & Treister, N. S. (2023).

Odontogenic tumors. Frontiers in Oral Health, 11. 

Autores: Mikami, T., González-Arriagada, W. A., Niklander, S. E., Gomes, C. C., Gomez, R. S., & Bologna-Molina, R. (2022)

Distribution and frequency of salivary gland tumours: an international multicenter study. Head and Neck Pathology, 1-12.

Autores: Alsanie, I., Rajab, S., Cottom, H., Adegun, O., Agarwal, R., Jay, A., …Gonzalez W & Khurram, S. A. (2022)

Difficulties in prognostic study of oral leukoplakia: standardization proposal of follow-up parameters. Frontiers in Oral Health. 2021;2:1.

Autores: Saldivia-Siracusa C, González-Arriagada WA.

Estimulación nerviosa eléctrica transcutánea como complemento a la terapia convencional en pacientes con trastornos temporomandibulares: un estudio caso-control. Avances en Odontoestomatología. 2020;36(4):208-17. 

Autores: Meeder Bella W, León-Morales C, Leissner O, Vergara-Bruna E, Maulén-Yañez M, González-Arriagada W.

Efficacy of copper sulphate on candida albicans on heat-polymerized acrylic resin. Journal of Oral Research. 2020;9(1):57-62. 

Autores: Huerta E, Gorup D, Manríquez M, Choappa RC, Oyarzo PV, González W.

Gerber-Mora R, y Lillo VP, Moreno-Silva R, González-Arriagada W.

Autores: Fine needle cytology features of an atypical presentation of infectious mononucleosis. Journal of oral and maxillofacial pathology: JOMFP. 2020;24(Suppl 1):S139.

Candidiasis of the tongue in cannabis users: A report of 2 cases. Gen Dent. 2020;68:66-8.

Autores: Faustino ISP, González-Arriagada WA, Cordero-Torres K, Lopes MA.

Leiomyoma of the sigmoid mesocolon associated to hemorrhagic infarct and high count of mast cells. World Journal of Colorectal Surgery. 2019;8(1):24-6. 

Autores:Lozano-Burgos C E-PC, González-Arriagada WA, Ochova-Gallardo P.

Araneda N, Parra M, González-Arriagada WA, Del Sol M, Haidar ZS, Olate S.

Autores: Morphological analysis of the human maxillary sinus using three-dimensional printing. Contemporary clinical dentistry. 2019;10(2):294.

Research Projects 

Guía de práctica clínica para la detección y diagnóstico del cáncer de la cavidad oral. Concurso de Investigación Interdisciplinaria y Asociativa UANDES-UFRO (Investigador Principal UANDES).

2023-2024

Herramienta de inteligencia artificial para la predicción y decisión de tratamiento de mucositis oral en pacientes oncológicos basado en Oral Mucositis Impact Scale for Cancer Patients. Inica tu Idea UFRO-UANDES (Investigador Principal UANDES).

2023-2024

Co-creando conocimiento: La experiencia de pacientes en el desarrollo de una línea de investigación para el manejo de las complicaciones orales de la terapia oncológica. Fondo BICI, Apoyo a la Investigación y Desarrollo Comprometidos con la Sociedad (Investigador Principal).

2023-2025

Oral Health eControl. Fondo de apoyo a la innovación sostenible UANDES (Investigador Principal).

2023

Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo (ID23I10325). Fondef (Co-investigador).

2023-2025

Preventing Hyposalivation and Salivary Gland Dysfunction following irradiation of the Head and Neck using Injectable and Release- Tunable Nano-sized dual-Drug Delivery System: Pre-clinical Safety and Efficacy Validation; a step closer to the clinic (ID22I10215). Fondef (Co-investigador).

2023-2024

Revealing the contribution of melanoma-derived circulating cell-free mitochondria in the formation of premetastatic niche in lymph nodes and their impact in the early development of metastasis (1230875). Fondecyt Regular (Co-investigador).

2023-2027

Observatorio epidemiológico interdisciplinario de salud oral en pueblos originarios de la Macrozona Norte de Chile (FOVI220161). Fomento a la vinculación Internacional para Instituciones de Investigación (Investigador Principal).

2023-2024

Role of CCL5/CCR5 Axis in The Aggressiveness of Oral Squamous Cell Carcinoma (1190775). Fondecyt Regular (Investigador Principal).

2019-2023

Análisis Morfológico 3D, Estereológico e Inmunohistoquímico de Sujetos con Asimetría Facial Asociada a de Hiperplasia Condilar Unilateral. Concurso de Proyectos de Investigación Red Estatal de Odontología. Convocatoria 2019 (Co-investigador).

2019-2020

Leukocyte and platelet-rich fibrin (L-PRF) obtained from smokers and nonsmokers shows a similar uniaxial-tensile response in vitro.

Aceptado para publicación 5 de diciembre.  

Autores: C. Lara, A. Bezmalinovic, C. García-Herrera, S. Ríos C, L.M. Valenzuela, Martínez, CE. 

Smoking habits do not affect biological responses induced by leucocyte and platelet-rich fibrin in periodontal ligament cells. 

J Oral Pathol Med. 2023 Feb;52(2):169-18 

Autores: Ríos S, Álvarez S, Smith PC, Sáez CG, Andrade C, Pinto N, Martínez CE. 0. doi: 10.1111/jop.13374. Epub 2022 Nov 22.  

Diabetes alters the involvement of myofibroblasts during periodontal wound healing.  

Autores: Retamal I, Hernández R, Velarde V, Oyarzún A, Martínez C, González MJ, Martínez J, Smith PC.  

Uncoupled inflammatory, proliferative, and cytoskeletal responses in senescent human gingival fibroblasts. 

Autores: Páez J, Hernández R, Espinoza J, Rojas L, Martínez C, Tobar N, Martínez J, Smith PC.  

Comparative effect of platelet-rich plasma, platelet-poor plasma, and fetal bovine serum on the proliferative response of periodontal ligament cell subpopulations. 

Autores: Martínez, C.E., Gómez, R., Kalergis, A.M. et al. 

Role of fibroblast populations in periodontal wound healing and tissue remodeling. 

Autores: Smith PC, Martínez C, Martínez J, McCulloch C.  

Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts. 

Autores: Retamal I, Hernández R, Melo F, Zapata P, Martínez C, Martínez J, Smith PC.  . 

Platelet Poor Plasma and Platelet Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells. 

Journal of Periodontology 87:e18-e262 

Autores: Martínez C, Gonzalez S, Palma V, Smith PC.  

Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells 

Autores: Retamal IN, Hernández R, González-Rivas C, Cáceres C, Arancibia R, Romero A, Martínez C, Tobar N, Martínez J, Smith PC.. 

The influence of platelet- derived products on angiogenesis and tissue repair: a concise update. 

Frontiers in physiology. 6:290, 1-7 

Autores: Martínez C, Smith P, Palma V.  

The influence of platelet- derived products on angiogenesis and tissue repair: a concise update. 

Journal of dental research 94(3) 

Autores: Martínez C, Smith P, Palma V.  

Gingival Wound Healing: An Essential Response Disturbed by Aging? 

Journal of dental research 94(3) 

Autores: Smith PC, Caceres M, Martínez C, Martínez J..  

Cigarette smoke condensate inhibits collagen gel contraction and prostaglandin E2 production in human gingival fibroblasts. 

Autores: Romero A, Caceres M, Arancibia R, Silva D, Couve E, Martínez C, Martínez J.  

Research on growth factors in periodontology 

Periodontology 2000 67(1) 

Autores: Smith PC, Martínez C, Caceres M, Martínez J 

Proliferation of murine midbrain neural stem cells depends upon an endogenous Sonic 2013 Hedgehog (Shh) source 

Autores: Martínez C, Cornejo VH, Lois P, Solis N, Palma V. 

Preparation and bioactive properties of novel bone- repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles.

Journal of Biomedical Materials Research: Part B – Applied Biomaterials. vol. 100B Nemerov 6, agosto 2012. p. 1672-1682 

Autores: Covarrubias C, Valenzuela F, Diaz-Dosque M, Smith P, Martínez C, Yazdani-Pedram M.  

Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties. 

Autores: Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties. 

Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties. 

Autores: Inzunza D, Covarrubias C, Marttens AV, Leighton Y, Carvajal JC, Valenzuela F, Díaz-Dosque M, Méndez N, Martínez C, Pino AM, Rodríguez JP, Cáceres M, Smith P.:  

Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation. 

Autores: Silva D, Caceres M, Arancibia R, Martínez C, Smith P. x. 

Effects of Platelet Rich and Poor Plasma on the reparative response of gingival fibroblasts. 

Autores: Caceres M, Martínez C, Martínez J, Smith P.  

Sonic Hedgehog Stimulates Proliferation of Human Periodontal ligament Stem Cells 

Autores: Martínez C, Smith P, Rodriguez JP, Palma V.

Dossier temático ciencias básicas, medicina oral, biotecnología y bioinformática en odontología 

Autores: Íngrid Johanna Garzón Bello , Constanza Eugenia Martínez Cardozo , Jaime Eduardo Castellanos Parra 

Células de glía envolvente olfatoria: potencial para la reparación de lesiones del sistema nervioso central.  

Autores: Gómez R, Neira A, Tovar D, Martínez C, Bernal J.

La proteina de estres heat shock cognate (HSC70) se sobreexpresa en osteoblastos sometidos a centrifugacion.  

Autores: Guerrero C, Martínez C, Sarmiento J, Cardozo C.

Estudio de Citotoxicidad in vitro de extractos de flora Colombiana usando el One Cell Test.  

Autores: Saul D, Mrad A, Martínez C, Cardozo C.

Hacia el conocimiento molecular del Metabolismo oseo: una revisión del estado del arte.  

Autores: Martínez C, Guerrero C, Sarmiento J, Cardozo C.

Normalización de Cultivos Celulares de Ligamento Periodontal Humano por Explantes.  

Autores:Martínez C, Guerrero C, Sarmiento J, Cardozo C.

“Crown-Root Angle Measurement in Permanent Central Incisors”

Autores: Pamela Zuñiga, Daniela Albers. 

Exploring the expressión of Pro-Inflamatory and Hipoxia-Related MicroRNA-20a, MicroRNA-30e, and MicroRNA-93 in Periodontitis and Gingival Mesenchymal Stem Cells under Hypoxia”

Autores: Alejandra Chaparro, Mauricio Loano, Dominique Gaedechens, Carolina Lopez, Daniela Albers, Marcela Hernandez, Andrés Pascual, José Nart and Carlos E. Irrazabal. 

Comparación de la salud oral integral de pacientes usuarios y no usuarios GES 60 años hospitalizados

Autores: Valentina Zaffiri, Claudia Cristoffanini, Daniela Albers, Verónica San Martín, Isidora Mujica, Guillermo Arenas

Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia

Autores: Alejandra Chaparro, Maximiliano Monckeberg, Ornella Realini, Marcela Hernandez ,Fernanda Param, Daniela Albers, Valeria Ramirez , Juan Pedro Kusanovic, Roberto Romero, Gregory Rice and Sebastian E. Illanes 

Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases -8 and -9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus 

Autores: Chaparro A., Realini O., Hernández M., Albers D., Weber L., Ramírez V., Param F., Kusanovic J.P., Sorsa T., Rice G., Illanes S 

Lymphocyte B and Th17 chematoctic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants 

Autores: Chaparro A., Sanz A., Wolnitzky A., Realini O., Bendek M., Betancur D., Albers D., Beltrán V.  

Molecular Signature of Extracellular Vesicles in Oral Fluidsof Periodontitis Patients 

Autor: Chaparro A., Aracena L., Realini O., Albers D., Hernández M., Ramírez V., Pascual A., Nart J., Beltrán V., Acuña-Gallardo S., Sanz A. 

First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study

Autor: Correa P., Venegas P., Palmeiro Y., Albers D., Rice G., Ro J., Cortez J., Monckeberg M., Schepeler M., Osorio E., Illanes S. 

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus

Autor: Chaparro A, Zúñiga E, Varas-Godoy M, Albers D, Ramírez V, Hernández M, Kusanovic JP, Acuña-Gallardo S, Rice G, Illanes SE 

Imagenología

Determination of presence and morphometry of lingual foramina and canals in Chilean mandibles using cone beam CT images

Autores: Soto R, Concha G, Pardo S, Cáceres F

The Presence of Lingual Foramina and Canals on CBCT on Patients over 18 Years of Age

Autores: Sanhueza A, Briner M, Calvo M, Cisternas A.

Presence and Morphometry of Lingual Foramina and Canal in Cone Beam CT of Chilean Dry Mandibles. Correlation with Direct Bone Measures

Autores: Cáceres F; Pardo S; Concha G; Soto R

Diagnostic assessment of skeletal maturity through dental maturation in Hispanic growing individuals
Autores: Cisternas A; Morales R; Ramirez V; Del Real A; Oyonarte R

Characterization of mandibular molar root and canal morphology using cone beam computed tomography and its variability in Belgian and Chilean population samples

Autores: Torres A; Jacobs R; Lambrechts P; Brizuela C; Cabrera C; Concha G; Pedemonte ME

Academic Achievement and Perception of Two Teaching Methods in Histology: Light Microscopy and Digital Systems

Autores: Becerra D; Grob M; Rodriguez A; Barker MJ; Consiglieri L; Ferri G; Sabag N.

Performance of the cephalometric asessment for sagital intermaxillary diagnosis. A narrative review

Autores: Castro Arenas MV; Hurtado Peralta M; Oyonarte Weldt R.

Patología Oral y Sistémica

Association between chronic periodontitis and rheumatoid arthritis. A systematic review

Autores: Wen S, Beltrán V, Chaparro A, Espinoza F, Riedemann JP.

MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients’, Mild and Severe Periodontitis Sites.

Autores: Hernández M, Baeza M, Contreras J, Sorsa T, Tervahartiala T, Valdés M, Chaparro A, Hernández-Ríos P.

Molecular signatures of extracellular vesicles in oral fluids of periodontitis patients.

Autores: Alejandra Chaparro Padilla, Laura Weber Aracena, Ornella Realini Fuentes, Daniela Albers Busquetts, Marcela Hernández Ríos, Valeria Ramírez Lobos, Andrés Pascual La Rocca, José Nart Molina, Victor Beltrán Varas, Stephanie Acuña-Gallardo, Antonio Sanz Ruiz.

Soluble Neuropilin-1 in gingival crevicular fluid from periodontitis patients: An exploratory cross-sectional study.

Autores: Prieto D, Maurer G, Sáez M, Cáceres F, Pino-Lagos K, Chaparro A.

Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study.

Autores: Prieto D, González C, Weber L, Realini O, Pino-Lagos K, Bendek MJ, Retamal I, Beltrán V, Riedemann JP, Espinoza F, Chaparro A.

Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis.

Autores: Hernández M, Baeza M, Räisänen IT, Contreras J, Tervahartiala T, Chaparro A, Sorsa T, Hernández-Ríos P.

Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis.

Autores: Jiménez C, Garrido M, Pussinen P, Bordagaray MJ, Fernández A, Vega C, Chaparro A, Hoare A, Hernández M.

CpG Single-Site Methylation Regulates TLR2 Expression in Proinflammatory PBMCs from Apical Periodontitis Individuals.

Autores: Hernández, Alejandra Chaparro, María Jesús Lira, Peter Gebicke-Haerter, Marcela Hernández.

High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric CancerPatients: Results of the FORCE1 Study.

Autores: Cordova-Delgado M, Pinto MP, Retamal IN,Muñoz-Medel M, Bravo ML, Fernández MF, Cisternas B, Mondaca S, Sanchez C, Galindo H, Nervi B, Ibáñez C, Acevedo, Madrid J, Peña J, Koch E1, Maturana MJ, Romero D, de la Jara N, Torres J, Espinoza M, Balmaceda C, Liao Y, Li Z, Freire M, Gárate-Calderón V, Cáceres J, Sepúlveda-Hermosilla G, Lizana R, Ramos L, Artigas R6, Norero E, Crovari F, Armisén R, Corvalán AH, Owen GI, Garrido M.

Morphology and Pathophysiology of the TMJ Fibrocartilage. Systemic review.

Autores: Gustavo Moncada, Rodrigo Millas, Constanza Valdés

Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study

Autores: Diego Prieto, Camila González, Laura Weber, Ornella Realini, Karina Pino-Lagos, Maria José Bendek, Ignacio Retamal, Víctor Beltrán, Juan Pablo Riedemann, Francisco Espinoza, Alejandra Chaparro

Condición oral de diabéticos tipo 2 hospitalizados durante los años 2015 y 2018. Estudio transversal

Autores: Mariana Cartens, M.Verónica San Martín, Yumiko

Autores: Tsukame, Verónica Astorga, Diego Prieto, M. Cristina Coloma, Guillermo Arenas

Academics’ and students’ experiences in a chilean dental school during the COVID‐19 pandemic: A qualitative study

Autores: Diego Prieto, Jorge Tricio, Felipe Cáceres , Fernanda Param, Catalina Meléndez, Pamela Vásquez, Pamela Prada

Difference in EGFR Expression and Mean Vascular Density in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.

Autores: Fernández A; Fernández J; Marshall M; Martínez R; Niklander S; Haidar ZS
Características Morfocuantitativas de la Glándula Submandibular de Ratón (Mus musculus)

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COVID-19 y la Odontología: una Revisión de las Recomendaciones y Perspectivas para Latinoamérica

Autores: EA Sigua-Rodríguez, JL Bernal-Pérez, AG Lanata-Flores, C Sánchez-Romero, J Rodríguez-Chessa, Z S Haidar, S Olate, L Iwaki-Filho

Augmento Óseo Horizontal de Reborde Alveolar en Sitio Atrófico Único en Maxila Anterior Usando Hidroxiapatita y rhBMP-2

Autores: G Maître, D Farias, E de-Moraes, R Sacco, R Ball, ZS Haidar,S Olate

Oral and pharyngeal cancer mortality in Chile, years 2002-2010

Autores: Ramirez V; Vásquez-Rozas P; Ramírez-Eyraud P

Principles for the treatment of odontogenic infections with different levels of complexity

Autores: Velasco IM; Soto R

Effects of periodontal therapy on markers of systemic inflammation in patients with coronary heart disease risk

Autores: López NJ; Quintero A; Llancaqueo M; Jara L

Susceptibility of Oral Candida Strains to Ethanol Extract of Chilean Propolis of Olmué

Autores: Natalia Maureira, Paulina Viera, Alejandra Fernandez, Madelein Urrejola, Cristian Bravo, Francisca Mardones, Enrique D. Vines, Ziyad S. Haidar

Fisiología y Fisiopatología Oral

Exploring the Expression of Pro-Inflammatory and Hypoxia Related MicroRNA-20a, MicroRNA-30e, and MicroRNA-93 in Periodontitis and Gingival Mesenchymal Stem Cells under Hypoxia.

Autores: Chaparro, A.; Lozano, M.; Gaedechens, D.; López, C.; Albers, D.; Hernández, M.; Pascual, A.; Nart, J.; Irarrazabal, C.E. Int. J. Mol. Sci.

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma

Autores: Fernández A; Fernández J; Marshall M; Martínez R; Niklander S; Haidar ZS

Oral and pharyngeal cancer mortality in Chile, years 2002-2010

Autores: Ramirez V; Vásquez-Rozas P; Ramírez-Eyraud P

RESILON Toxic to Oral Squamous Carcinoma Cells: A Live/Dead Assay

Autores: Jimenez C; Haidar ZS

Academic Achievement and Perception of Two Teaching Methods in Histology: Light Microscopy and Digital Systems

Autores: Becerra DG; Grob DLP; Rodríguez AR; Barker MJM; Consiglieri LL; Ferri GG; Sabag NS

Functional compartmentalization of the human superficial masseter muscle.

Autores: Guzmán-Venegas RA; Biotti Picand JL; de la Rosa FJB.

Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives.

Autores: Dohan Ehrenfest DM; Andia I; Zumstein MA; Zhang CQ; Pinto NR; Bielecki T.

Células Madres en Odontología y Regeneración Celular

Proliferation of mesenchymal stem cells from human gingival tissue on chitosan scaffold: an in vitro study

Mesenchymal Stem Cells Derived from Human Inflamed Dental Pulp Exhibit Impaired Immunomodulatory Capacity In Vitro

Autores: Carolina Inostroza, Ana María Vega-Letter, Claudia Brizuela, Luis Castrillon, Nicole Saint Jean, Carol Mira Duran, and Flavio Carrion.

Low-Level Laser Irradiation Promotes Proliferation and Differentiation on Apical Papilla Stem Cells

Autores: David Gutiérrez, Mahmoud Rouabhia, Javiera Ortiz , Diego Gaviria, Camilo Alfonso, Ana Muñoz , Carolina Inostroza.

Mesenchymal Stem Cells Derived from Human Inflamed Dental Pulp Exhibit Impaired Immunomodulatory Capacity In Vitro

Autores: C Inostroza, AM Vega-Letter, C Brizuela, L Castrillón, N Saint Jean, C Mira Duran, F Carrión

Gingival Mesenchymal Stem Cells Outperform Haploidentical Dental Pulp-derived Mesenchymal Stem Cells in Proliferation Rate, Migration Ability, and Angiogenic Potential.

Autores: Angelopoulos I, Brizuela C, Khoury M

Evaluación de la Proliferación de Células Madres Mesenquimales Estimuladas con Diferentes Intensidades de Ultrasonido de Baja Intensidad.

Autores: Becerra D; Díaz J; Carrión F; Inostroza C; Oyonarte R.

Isolation and characterization of mesenchymal stem cells from pulp and human dental follicleIsolation and characterization of mesenchymal stem cells from pulp and human dental follicle

Autores: Brizuela C; Galleguillos S; Carrión F; Cabrera C; Luz P; Inostroza C.

Biocompatibilidad de Células Madres Mesenquimales de Tejido Gingival Humano en Cultivo con un Andamiaje de Polímero Sintético de Ácido Poliláctico (OPLA).

Autores: Brizuela C; Saint Jean N; Inostroza C.

Propuesta de un modelo para lograr la revascularización pulpar de un diente inmaduro con periodontitis apical asintomática utilizando fibrina rica en plaquetas: Informe preliminar.

Autores: Brizuela C.

Culture and Characterization of Mesenchymal Stem Cells From Human Gingival Tissue

Autores: Mitrano T; Grob M; Carrión F; Nova-Lamperti E; Luz P; Fierro F; Quintero A; Chaparro A; Sanz A

Proliferation of mesenchymal stem cells from human gingival tissue on chitosan scaffold: an in vitro study

Autores: Hernández BM; Inostroza VC; Carrión AF; Chaparro PA; Quintero HA; Sanz RA

Biomarcadores y Embarazo

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus.

Autores: Chaparro A, Zúñiga E, Varas-Godoy M, Albers D, Ramírez V, Hernández M, Kusanovic JP, Acuña-Gallardo S, Rice G, Illanes SE.

Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus.

Autores: Monteiro LJ, Varas-Godoy M, Monckeberg M, Realini O, Hernández M, Rice G, Romero R, Saavedra JF, Illanes SE, Chaparro A.

Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and -9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus.

Autores: Chaparro A, Realini O, Hernández M, Albers D, Weber L, Ramírez V, Param F, Kusanovic JP, Sorsa T, Rice GE, Illanes SE.

Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia.

Autores: Chaparro A, Monckeberg M, Realini O, Hernández M, Param F, Albers D, Ramírez V, Kusanovic JP, Romero R, Rice G, Illanes SE.

Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle.

Autores: Bendek MJ, Canedo-Marroquín G, Realini O, Retamal IN, Hernández M, Hoare A, Busso D, Monteiro LJ, Illanes SE, Chaparro A.

Obesity is related to maternal periodontitis severity in pregnancy: a cross-sectional study

Autores: Ramírez V, Weber L, Hernández M, Realini O, Bendek MJ, Busso D, Hoare A, Illanes SE, Chaparro A.

Relationship between soluble neuropilin-1 in the gingival crevicular fluid of early pregnant women and different severities of periodontitis: A cross-sectional study.

Autores: Prieto D, Pino-Lagos K, Realini O, Cáceres F, Retamal I, Chaparro A.

Diagnostic accuracy of placental alkaline phosphatase concentrations in gingival crevicular fluid at early pregnancy in predicting the risk of preeclampsia: a prospective cohort study

Autores: A Chaparro, M Monckeberg, O Realini, Marcela Herna ́ndez4, Fernanda Param3, D Albers, V Ramirez, JP Kusanovic, R Romero, G Rice, and S Illanes
REVISTA: Authorea

Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus

Autores: Lara J. Monteiro, Manuel Varas-GodoyID, Max Monckeberg, Ornella Realini, Max Monckeberg, Ornella Realini, Marcela Hernandez, Gregory Rice, Roberto Romero, Jose´ F. Saavedra, Sebastia´n, E. Illanes, Alejandra Chaparro

Oral Health Status of Hospitalized Pregnant Women Users of the Pregnancy Ges Program in Chile Compared to not Users: A Cross Sectional Study

Autores: San Martín H. V.; Wiliams, D. C.; Tsukame, K. Y.; Carstens, A. M.; Coloma, O. M. C.; Lorenzo, V. M. & Arenas, V. G.

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus.

Autores: Chaparro A,Zúñiga E, Varas‐Godoy M, Albers D, Ramírez V, Hernández M, Kusanovic JP, Acuña‐Gallardo S, Rice G, Illanes S.

Is the risk of preeclampsia higher in donor oocyte pregnancies? A systematic review and meta-analysis.

Autores: Juan Enrique Schwarze, Paula Borda, Pamela Vásquez, Carolina Ortega, Sonia Villa, Javier A. Crosby, Ricardo Pommer

IFPA meeting 2015. workshop report II: mechanistic role of the placenta in fetal programming; biomarkers of placental function and complications of pregnancy

Autores: Andraweera, P. H.; Bobek, G.; Bowen, C.; Burton, G. J.; Correa Frigerio, P.; Chaparro, A.; Dickinson, H.; Duncombe, G.; Hyett, J.; Illanes, S. E.; Johnstone, E.; Kumar, S.; Morgan, T. K.; Myers, J.; Orefice, R.; Roberts, C. T.; Salafia, C. M.; Thornburg, K. L.; Whitehead, C. L.; Bainbridge, S. A

Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia

Autores: Chaparro A; Gaedechens D; Ramirez V; Zuñiga E; Kusanovic JP; Inostroza C; Varas-Godoy M; Silva K; Salomon C; Rice G;Illanes SE

Detection of CD63+ micro-vesicles, placental alkaline phosphatase and angiogenic markers in gingival crevicular fluid in preeclamptic patients

Autores: Chaparro A; Zuñiga E; Gaedechens D; Ramírez V; Inostroza C; Kusanovic JP; Silva K; Rice GE; Illanes SE

Porphyromonas gingivalis, Treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case–control study.

Autores: Porphyromonas gingivalis, Treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case–control study.

Increased inflammatory biomarkers in early pregnancy is associated with the development of preeclampsia in patients with periodontitis: a case control study.

Autores: Chaparro A; Sanz A; Quintero A; Inostroza C; Ramirez V; Carrion F; Figueroa F; Serra R; Illanes SE

Association between chronic periodontitis, interleukin-6 (IL-6) and body mass index (BMI) in pregnant women

Autores: Mella S; Inostroza C; Sanz A; Quintero A; Illanes S; Carrión F; Ramírez V; Chaparro A