Resultados

Diego Morales

Tesis: Type 2 diabetes transmission by a Prion-like mechanism.
Tutor: Maroun Khoury
Co-tutor: Fernando Figueroa

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Enrique Armijo

Tesis: Cell therapy for Alzheimer’s disease using induced pluripotent stem cells (iPSCs).
Tutor: Claudio Soto
Co-tutor: César González

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Luis Cataldo

Tesis: Efecto de la activación del receptor de serotonina Htr2b en la regulación de la secreción de insulina y la función mitocondrial en la célula β-pancreática.
Tutor: José Luis Santos
Co-tutor: Victor Cortés

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María José Torres

Tesis: The impaired immunosuppressive potential of menstrual blood in comparison with bone marrow-derived stem cells raises concern regarding their clinical use.
Tutor: Maroun khoury
Co-tutor: Fernando Figueroa

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Javiera Bravo

Tesis: Evaluation of prion-like properties of amyloid-B aggregates in vivo.
Tutor: Claudio Soto
Co-tutor: Rodrigo Morales

Luis Miguel Concha

Tesis: Detection of human prions in bodily fluids and peripheral tissues.
Tutor: Claudio Soto

Solange Massa

Tesis: Engineering ´hepatic’ in vitro platforms for drug toxicity testing.
Tutor: Juan Pablo Acevedo
Co-tutor: Ali Khademhosseini

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Carlos Kramm

Tesis: Detection of chronic wasting disease (CWD) prions in biological and environmental samples.
Tutor: Rodrigo Morales
Co-tutor: Claudio Soto

Rafael Contreras

Tesis: Glycolytic Metabolism Regulates the Immunosuppressive and Therapeutic Properties of Mesenchymal Stem Cells: Role of PPARβ/δ and HIF1α Activity
Tutor: Patricia Luz-Crawford
Co-tutor: Farida Djouad

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Ariel Caviedes

Tesis: eNOS  en neuronas regula la activación del factor de transcripción NF-kB y la experesión de sus genes blanco.
Tutor: Úrsula Wyneken

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Nicolás Pinto

Tesis:  Participación de la quinasa Cdk5 en los mecanismos celulares y moleculares del dolor dental.
Tutor: Elias Utreras
Co-tutor: Carlos Lafourcade

Anllely Fernández

Tesis: Sumoylation Regulates Protein Cargo in Small Extracellular Vesicles
Tutor: Úrsula Wyneken
Co-tutor: Alejandro Rojas

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Mónica Kurte

Tesis: MSCs IMMUNOPLASTICITY IS COMMANDED BY A SINGLE LPS STIMULUS WITH TIME-VARIABLE EXPOSURE LEADING TO OPPOSITE THERAPEUTIC OUTCOME, INVOLVEMENT OF SOCS3 EXPRESSION IN THE TLR4-DEPENDANT MSCs PHENOTYPE CONVERSION
Tutor: Maroun Khoury
Co-tutor: Vinivicus Maracja

Mónica Kurte. Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis. F.Stem Cells Int.

Carolina Echeverría. Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population. Tumour Biol

Mónica Kurte. Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model. Cytotherapy.

Mónica Kute. Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels. PLoS One.

Mónica Kurte. Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE.. Stem Cell Res Ther.

Albano Cáceres. Cáncer Bucomaxilofacial en Niños III: Tumores Malignos del Tejido Blando. International. Journal of Odontostomatology.

Carmen Hidalgo. Artificial Mitochondria Transfer: Current Challenges,Advances, and Future Applications. Stem Cells International.

Carolina Echeverría. Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population [published correction appears in Pathol Oncol Res

Sergio Viáfara. Rosuvastatin inhibits interleukin (IL)-8 and IL-6 production in human coronary artery endothelial cells stimulated with Aggregatibacter actinomycetemcomitans serotype b. Journal of Periodontology.

Cristina Padilla. Improving myoblast differentiation on electrospun poly(ε-caprolactone) scaffolds. J Biomed Mater Res A.

Cristina Padilla. Chitosan/poly-octanoic acid 2-thiophen-3-yl-ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro. J Biomed Mater Res.

Fujiko Saavedra. On biophysical properties and sensitivity to gap junction blockers of connexin 39 hemichannels expressed in HeLa Cells. Front. Physiol.

Fujiko Saavedra. Sepsis-Induces channelopathy in skeletal muscles is associated with expression of non-selective channels. Shock.

Eliana Lara. Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches. Crit Rev Microbiol

Mónica Kurte. The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration. Front Physiol.

Mónica Kute. IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis. Front Immunol

Sergio Viáfara. Eikenella corrodens lipopolysaccharide stimulates the pro-atherosclerotic response in human coronary artery endothelial cells and monocyte adhesion. European Journal of Oral Sciences.

Sergio Viáfara. Effect of bisphosphonates on orthodontic tooth movement in osteoporotic patients: A review. Journal of the World Federation of Orthodontists

Cristina Padilla. Stress transfer and matrix-cohesive fracture mechanism in microfibrillated cellulose-gelatin nanocomposite films. Carbohydr Polym

Albano Cáceres. Angiogenic properties of menstrual stem cells are impaired in women with a history of preeclampsia. Stem Cells Int.

Albano Cáceres. Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells. Int J Mol Sci

Masyelly Rojas. CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner. Front Immunol.

Sergio Viáfara. Repeated Porphyromonas gingivalis W83 exposure leads to release pro-inflammatory cytokynes and angiotensin II in coronary artery endothelial cells. Scientific Reports.

Cristina Padilla. Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering. Mater Sci Eng C Mater Biol Appl.

Cristina Padilla. Characterization and testing of a novel sprayable crosslinkededible coating based on salmon gelatin. Coatings

Mónica Kurte. Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response. EMBO Rep.

Mónica Kurte. Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE. Stem Cell Research an Therapy.

Albano Cáceres. Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells. Sci Rep.

Noymar Luque. HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions. FASEB J.

Noymar Luque. PPARß/d-dependent MSC metabolism determines their immunoregulatory properties. Scientific Reports.

Noymar Luque. Role of AMP activated protein kinase in the immunotherapeutic activity of metabolically reprogramed mesenchymal stem cells into a glycolytic metabolism. Molecular Therapy.

María José Bendek. Lymphocyte B and Th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri- mucositis, and peri-implantitis implants. J Oral Res

• Enrique Armijo. HIV/AIDS: modified stem cells in the spotlight. Cellular and Molecular Life Sciences
• Luis Cataldo. Role of peripheral serotonin in the insulin secretion and glucose homeostasis. NUTRICION HOSPITALARIA
• Luis Concha. Prions in the Urine of Patients with Variant Creutzfeldt- Jakob Disease. NEW ENGLAND JOURNAL OF MEDICINE.
• Luis Concha. The Extent of Protease Resistance of Misfolded Prion Protein is Highly Dependent on the Salt Concentration. JOURNAL OF BIOLOGICAL CHEMISTRY

• Javiera Bravo. Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer’s disease. Scientific Reports
• Luis Cataldo. Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 β-cells. Experimental and Clinical Endocrinology & Diabetes
• Mónica Kurte. Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis. Stem Cells International
• Diego Morales. Type 2 diabetes as a protein misfolding disease. Trends in Molecular Medicine.
• Solange Massa. Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink. Advanced Materials
• Solange Massa. Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Actuators. Scientific Reports
• Solange Massa. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication

• Rafael Contreras. Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression. Stem cells international
• Mónica Kurte. Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE. Stem Cell Research and Therapy
• Mónica Kurte. Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels. PLOS One
• Solange Massa. Platinum nanopetal-based potassium sensors for acute cell death monitoring. RSC Advances

• Rafael Contreras. Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay. Theranostics
• Rafel Contreras. IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology
• Mónica Kurte. IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology
• Mónica Kurte. The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration. Frontiers in Physiology
• Solange Massa. Bioprinted 3D vascularized tissue model for drug toxicity análisis. Biomicrofluidics
• Nicolás Pinto. TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons. Frontiers in Physiology

• Rafael Contreras. Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response. Frontiers in Immunology
• Rafael Contreras. From bench to bedside of mesenchymal Stem Cells use for Rheumatoid Arthritis treatment. Springer Nature
• Noymar Luque. Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response. Frontiers in Immunology
• Noymar Luque. From bench to bedside of mesenchymal Stem Cells use for Rheumatoid Arthritis treatment. Springer Nature

• Albano Cáceres. Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells. International Journal of Molecular Sciences.
• Albano Cáceres. Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells. Scientific Reports.
• Rafael Contreras. Differentiation of adipose-derived stem cells to functional CD105neg CD73low melanocyte precursors guided by defined culture condition. Stem Cell Research and Therapy.
• Noymar Luque. Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer. Stem Cell Research and Therapy.
• Enrique Armijo. Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70). Journal of Biological Chemistry.
• Luis Concha. Preclinical Detection of Prions in Blood of Nonhuman Primates Infected with Variant Creutzfeldt-Jakob Disease. Emerging Infectious Diseases.
• Rafael Contreras. PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties. Scientific Reports.
• Rafael Contreras. HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions. FASEB Journal.
• Carlos Kramm. Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70). Journal of Biological Chemistry.
• Mónica Kurte. Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response. EMBO reports.
• Noymar Luque. PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties. Scientific Reports.
• Noymar Luque. HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions. FASEB Journal.